A rare leukemia treated with chemotherapy – not a bone marrow transplant – leads to remission

Steve, a Goodyear resident, was having alarming symptoms. "I had a mass on my chest the size of a baseball," he said. "I couldn't swallow, I couldn't eat and I couldn't sleep."

He went to his primary care doctor who referred him to a cancer specialist. That doctor told Steve he had a type of leukemia called T-cell acute lymphoblastic leukemia, or ALL, a rare cancer. The specialist referred him to the HonorHealth Cancer Transplant Institute.

An event manager for the American Liver Foundation, Steve was expecting to hear that he would need a bone marrow transplant, also called a stem cell transplant.

Though he would have been a good candidate for stem cell transplantation, "based on his disease and donor status (his donor's bone marrow wasn't a 100% tissue match) and response to therapy, we felt that chemo was a better approach rather than stem cell transplantation," said Veena Fauble, MD, a hematologist and medical oncologist and independent member of the HonorHealth Medical Staff. 

Steve underwent an intense prescribed course of chemotherapy. It was first developed for children with this type of leukemia and recently expanded to young adults under 40. Steve was 34 at the time of his diagnosis.

Instead of a bone marrow transplant, Steve received an infusion (intravenously) of a combination of eight chemotherapy drugs five or six days a week for eight to 10 hours a day for roughly six months. After that, he began a maintenance course of an oral chemotherapy drug every day and an infusion of another chemotherapy drug every four weeks.

Steve says an optimistic attitude kept him going through the intense chemotherapy treatment and continues to inspire him every day.

"He is a very positive person with excellent family support," said Dr. Fauble. "He has always been determined to do well and he just puts one foot in front of the other and keeps his head up high."

On the road to a cure

Although Steve won't be considered cured until the five-year mark of his diagnosis, his prognosis is good, Dr. Fauble says. "He is in complete remission and doing well. If he is able to complete all of the maintenance cycles of this protocol, his outcome is very good."

Undergoing this treatment regimen wasn't easy for Steve, who is married and is the father of a 7-year-old boy. "But my life is as normal as it can be," he said. "And I'm grateful that I've had such good results from the treatment."

Leukemia treatment leads to remission - Read Steve's HonorHealth patient story

Care that's made for you

HonorHealth's Cancer Transplant Institute provides expert care for a wide range of non-cancerous blood disorders and blood malignancies, including the various types of leukemias, lymphomas and myelomas.

Learn more